Group C adenovirus DNA sequences in human lymphoid cells
نویسندگان
چکیده
منابع مشابه
Do highly oncogenic group A human adenoviruses cause human cancer? Analysis of human tumors for adenovirus 12 transforming DNA sequences.
Adenovirus 12 (Ad12) (Huie) (highly oncogenic group A) readily induces tumors in newborn rodents. Since Ad12 is isolated from human fecal samples, we investigated whether it plays a role in the etiology of human gastrointestinal cancer. If Ad12 is a causal agent of human cancer, then human tumors should contain Ad12 transforming genes, as indicated by studies of cells transformed in vitro and i...
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Three major DNA polymerases have been identified in soluble extracts from eukaryotic cells (1). One is a high molecular weight enzyme (about 150,000 daltons), found predominantly in cytoplasmic fractions, which we refer to as DNA polymerase C (1-4). The second is a lower molecular weight form (about 40,000 daltons), which is recovered primarily from nuclei (but also present in cytoplasm), which...
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The present study was undertaken to investigate the potential role of glucocorticoid-induced DNA damage in the lysis of human lymphoid leukemia cells by glucocorticoids. Lymphoblasts were isolated from patients with acute lymphoblastic leukemia (ALL) or chronic myelogenous leukemia (CML) in blast crisis and cultured in vitro with or without dexamethasone. DNA was then purified from the cells an...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1986
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.59.1.189-192.1986